Self published ebooks on Amazon and Barnes and Noble seem to be the smartest way to sell an ebook right now. This USA Today article tells the story of Amanda Hocking, whose self-published "Trylle Trilogy" has found itself into the top selling books list.
This makes me believe my own paranormal romance series could work. It is about a night archives librarian who is secretly a vampire. When he is forced to teach a class on bibliometrics, he finds love with a girl who is also in love with a werewolf reference librarian. This is compounded when the vampire that made him, a children's librarian from Transylvania, begins working in town. I call it "Bite Me in the Stacks."